In obstructive sleep apnoea, that question may be more important than we think. A timely review by Gruber et al. in the European Respiratory Review highlights a frequently overlooked phenotype: nocturnal hypertension and impaired dipping in patients with OSA.
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For years, pharmacologic targeting of aldosterone has largely meant blocking its action at the mineralocorticoid receptor. Now, aldosterone synthesis itself has become a therapeutic target. In a timely article published…
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A new drug-level network meta-analysis including 10 RCTs and 2,865 patients provides an interesting perspective on therapies targeting the aldosterone-related sodium-retention pathway. Compared with placebo, office…
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